The Serene Farms Guide to THCA: What It Is, How It’s Made, Benefits, and Safety

Tetrahydrocannabinolic acid (THCA) is one of the lesser-known but highly significant compounds found in cannabis. Unlike its more famous cousin THC (tetrahydrocannabinol), THCA is non-psychoactive in its raw form but becomes psychoactive when activated by heat. Due to THCA being hemp derived and being Federally legal and legal in most states, the cannabinoid has recently exploded in popularity. In this guide, we’ll break down what THCA is, how it’s made, how it can be consumed, its potential benefits, and its safety profile. 

What Is THCA?

THCA stands for tetrahydrocannabinolic acid, the precursor to THC. THCA is found in raw and freshly harvested cannabis, and it is only when THCA is exposed to heat that it is converted into THC through a process called decarboxylation. This is why raw cannabis doesn’t produce the “high” associated with cannabis use — THCA itself is non-psychoactive. Once the raw cannabis is smoked, vaporized, or baked, the THCA converts into THC, which interacts with the body’s endocannabinoid system and produces the well-known euphoric effects.

How THCA Is Produced

THCA is naturally produced in the trichomes of cannabis plants. Here’s a basic overview of how THCA is created:

1. Cannabinoid biosynthesis: THCA is synthesized in the cannabis plant through a biochemical process. Cannabigerolic acid (CBGA), often referred to as the “mother of all cannabinoids,” serves as the precursor for the formation of THCA. Through enzymatic reactions, CBGA is converted into THCA as the plant grows and matures.
2. Fresh cannabis: THCA is abundant in freshly harvested cannabis. In its raw form, cannabis will contain mostly THCA and very little THC, making it non-psychoactive until heat is applied.
3. Decarboxylation: When THCA is exposed to heat, the acid group (COOH) is removed, transforming it into THC. This process occurs naturally when cannabis is smoked, vaporized, or cooked into edibles.

How to Consume THCA

While THCA is most often converted into THC during consumption, it can also be ingested in its raw form to take advantage of its potential therapeutic benefits without psychoactive effects. Here are several ways to consume THCA:

1. Raw cannabis: Consuming raw cannabis leaves or buds in smoothies, salads, or juices is one way to ingest THCA without converting it into THC. This is a popular method for those who want the potential health benefits of THCA without the psychoactive effects of THC.
2. THCA tinctures: Some companies produce THCA tinctures that allow you to ingest THCA sublingually (under the tongue) or by adding it to food or drinks. These tinctures typically come in cold-extracted forms to preserve the THCA content.
3. THCA capsules: THCA capsules are a convenient option for those who want a controlled dose of THCA. Since these capsules are not exposed to heat, the THCA remains in its non-psychoactive form.
4. Topicals: THCA-infused topicals, such as creams and balms, are available for localized relief from pain and inflammation without any psychoactive effects.
5. Vaping or smoking: When THCA-rich cannabis is smoked or vaped, the compound is converted into THC. This method allows users to experience the psychoactive effects of THC along with any therapeutic effects that may come from other cannabinoids and terpenes.

Potential Benefits of THCA

While research into THCA is still ongoing, early studies and anecdotal evidence suggest that this cannabinoid may offer a wide range of potential therapeutic benefits. Below are some of the most promising effects associated with THCA:

1. Anti-inflammatory properties: THCA has been shown to have anti-inflammatory effects, making it potentially beneficial for people with conditions like arthritis, lupus, or Crohn’s disease. Its ability to reduce inflammation without the psychoactive effects of THC makes it appealing to those seeking relief without the high.
2. Neuroprotective effects: Some studies suggest that THCA may have neuroprotective properties, which could make it useful in treating neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Its antioxidant activity could help prevent oxidative stress in the brain, which is a contributor to these diseases.
3. Nausea and appetite stimulation: THCA has shown potential in reducing nausea and stimulating appetite, similar to THC but without the psychoactive effects. This could make it a promising treatment for conditions like nausea caused by chemotherapy or appetite loss related to chronic illness.
4. Pain relief: THCA may have analgesic (pain-relieving) properties. While its effects on pain may not be as immediate or as strong as THC’s, its ability to reduce inflammation could indirectly help manage pain, particularly for chronic pain conditions.
5. Antiemetic properties: Early studies indicate that THCA may help reduce vomiting and nausea, which could benefit patients undergoing chemotherapy or those with chronic gastrointestinal issues.
6. Anti-proliferative effects: Some preliminary research suggests that THCA may have anti-proliferative effects, meaning it could slow or stop the growth of cancer cells. However, much more research is needed to fully understand this potential benefit.

Is THCA Safe?

THCA is considered safe, especially when used in its raw, non-psychoactive form. Since THCA doesn’t produce the same intoxicating effects as THC, it can be consumed by those looking for potential health benefits without the high. However, as with any cannabinoid, it’s important to consider some safety factors:

• Lack of long-term research: While THCA appears to have a promising therapeutic profile, there is still limited long-term research available on its effects. It’s advisable to approach THCA with caution if you have underlying health conditions or are taking medications, and always consult with a healthcare professional if you are unsure.
• Drug interactions: Although THCA itself may not interact with medications in the same way THC does, it’s still wise to consult a healthcare provider if you’re on medication or have health concerns. THCA could potentially interact with drugs that are metabolized by the liver, though more research is needed to confirm this.
• Sensitivity: As with any cannabis-derived product, some individuals may have sensitivities to cannabinoids. If you experience any adverse reactions, such as nausea, dizziness, or allergic reactions, discontinue use and consult a healthcare provider.

THCA vs. THC: What’s the Difference?

The key difference between THCA and THC is that THCA is non-psychoactive, while THC is responsible for the “high” associated with cannabis use. However, THCA and THC are closely related, as THCA is converted into THC when exposed to heat.

• Psychoactivity: THCA does not bind to cannabinoid receptors in the same way that THC does, meaning it won’t get you high unless decarboxylated (heated) into THC.
• Legal status: In some regions where THC is restricted or illegal, THCA may be legal to purchase and consume, provided it hasn’t been converted into THC. However, laws vary by jurisdiction, and it’s important to verify local regulations.
• Medical uses: While THC is often used for its psychoactive effects, THCA is typically sought out for its potential therapeutic benefits, such as reducing inflammation or nausea, without producing intoxication.

How to Store THCA

If you want to preserve the THCA content in your cannabis, it’s essential to store it properly to avoid decarboxylation. Here are some tips for storing THCA-rich cannabis:

1. Keep it cool: Heat is the primary cause of THCA converting into THC, so store your cannabis in a cool, dark place. Avoid exposing it to high temperatures or direct sunlight.
2. Use airtight containers: Exposure to air and moisture can degrade cannabinoids, including THCA. Keep your cannabis in airtight containers to preserve its potency.
3. Avoid long-term exposure to light: UV light can also degrade cannabinoids over time. Store cannabis in opaque containers or in a dark location to extend its shelf life.

Implications on Drug Testing

If your job or other aspects of your life do not allow for consumption of THC and you may be drug tested for any reason we would recommend avoiding products with this cannabinoid. THCA can most definitely help you fail a drug test. We would recommend trying our products with CBD, CBG and/or CBN. 

Final Thoughts

THCA is an intriguing cannabinoid with a range of potential therapeutic applications. Its non-psychoactive nature makes it appealing to those who want to harness the health benefits of cannabis without the intoxicating effects of THC. From reducing inflammation and nausea to possibly protecting the brain, THCA offers a wealth of possibilities for wellness.

As research continues to expand, we are likely to learn even more about the full range of benefits THCA may offer. Whether you’re interested in consuming raw cannabis, using THCA tinctures, or exploring its potential as a therapeutic agent, THCA is a promising cannabinoid worth exploring.

As always, it’s important to start with a low dose, especially if you’re new to cannabis or trying THCA for the first time. Be sure to consult with a healthcare provider if you have any concerns about how THCA may interact with your health or medications. Do not consume if you are pregnant. 

Currently Serene Farms does not feature THCA in any products but we have a couple items coming soon!